Short CV - "Rocasolano", CSIC

Juan A. Hermoso - CV
CURRICULUM VITAE
JUAN A. HERMOSO
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
SPANISH NATIONAL RESEARCH COUNCIL
NAME
WORKING ADDRESS
Juan A. Hermoso
Dept. of Crystallography & Structural Biology, Institute of Physical-Chemistry “Rocasolano”
Consejo Superior de Investigaciones Científicas, Serrano 117, 28006-Madrid (Spain)
Telf. +34 917459538, Fax: +34 91 585 5119, Email: [email protected]
CURRENT POSITION
Full Professor (Prof. de Investigación CSIC)
ACADEMIC & RESEARCH TRAINING
20091999-2008
1996-1998
1995
1994-1995
1993-1994
Research Professor (CSIC)
Tenured Scientist (CSIC)
Associate Scientist (CSIC)
Associate Scientist IBS (CEA-CNRS), Grenoble (France)
Postdoctoral Fellow (Inst. Biologie Structurale- IBS), Grenoble (France)
Postdoctoral Fellow (Laboratoire de Crystallographie CNRS), Grenoble (France)
DEGREES
1992
1988
Ph.D. Thesis in Physics, Univ. Complutense, Madrid (Spain)
Master Degree in Pysics, Univ. of Salamanca, Salamanca (Spain)
MEMBERSHIP IN PROFESSIONAL SOCIETIES
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American Society for Biochemistry and Molecular Biology (ASBMB).
Spanish Society for Biochemistry and Molecular Biology (SEBBM).
Spanish Society for Biophysics.
Spanish Group of Crystallography (GEC).
Spanish Synchrotron Radiation Users Organization (AUSE).
PROFESSIONAL ACTIVITIES
2009201520072003-2011
2000-2010
2007-2015
2009-2010
2000-
Research Professor at the Department of Crystallography (CSIC)
Adjunct ANEP (Spanish National Agency for Scientific Evaluation) in Fundamental and Systems
Biology Area (Structural Biology).
Review Committee of beamlines BM25 (ESRF, Grenoble) and XALOC (ALBA, Barcelona).
Councilor of the Spanish Synchrotron Radiation Users Organization Committee (AUSE)
Councilor of the Spanish Group of Crystallography (GEC)
Scientific Comity of the Spanish beamline BM25 at the ESRF. Grenoble
Scientific Committee (Sub-Committee 8 (Biology)) of the ILL. Grenoble
Ad hoc reviewer for the Spanish Ministry of Research, Natural Sciences and Engineering Research
Council of Canada (NSERC), Research Council of Spain, French Ministry of Research (ANR),
National Science Foundation of Colombia (COLCIENCIAS), National Science Foundation of
Argentina (FONCYT)
PUBLICATIONS
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More than 148 publications in international journals and co-author of 9 books
Citations: According to ISI’s Web of Science, on January 2016 there were 3377 citations to my work (H-index =
33, i10 index=79).
Over 60 invited conferences
AWARDS
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“Manuel Rico- Bruker” 2015 award of the Spanish Society of Biophysics.
RESEARCH PROFILE (http://www.xtal.iqfr.csic.es/grupo/xjuan/).
The research carried out in my group employs a multidisciplinary approach with X-ray crystallography, Protein
Engineering and Bioinformatics tools aiming to provide knowledge of the three-dimensional structure of proteins
and analysis of their various interactions and ligand complexes as a prerequisite for an in-depth understanding of
any biological process.
The research interests in my group encompass studies in the mechanisms of virulence and pathogenesis and the
means of circumvent them. We focus on the structural biology of the pneumococcal surface proteins involved in
key functions, such as binding of the pathogen to host cellular receptors, oxidative stress resistance mechanisms,
pathogenesis mechanisms or the remodeling of the peptidoglycan framework, which represent important
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Juan A. Hermoso - CV
mechanisms in the process of disease. The mechanisms of action of endolysins (phage-encoded enzymes that
break down bacterial peptidoglycan) are also studied as potential pharmaceutical agents (enzybiotics).
SELECTION OF MOST RECENT ARTICLES (SINCE 2005)
(for a full list follow this link)
• Bouley, R.; Kumarasiri, M.; Peng, Z.; Otero, L.; Song, W.; Suckow, M.; Schroeder, V.; Wolter, W.; Lastochkin,
E.; Antunes, N.; Pi, H.; Vakulenko, S.; Hermoso, J.; Chang*, M. and Mobashery*, S. Discovery of Antibiotic (E)3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. J. Am. Chem. Soc. (2015), 137, 1738−1741.
Impact Factor: 12.11
• Jennifer Fishovitz, Alzoray Rojas-Altuve, Lisandro H Otero, Matthew Dawley, Cesar Carrasco-López, Mayland
Chang, Juan A Hermoso* & Shahriar Mobashery*
Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J. Am. Chem.
Soc. (2014); 136, 9814–9817.
Impact Factor: 12.11
• Sergio G. Bartual, Daniel Straume, Gro Anita Stamsås, Inés G. Muñoz, Carlos Alfonso, Martín Martínez-Ripoll,
Leiv Sigve Håvarstein* & Juan A. Hermoso *
Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae.
Nature Communications (2014); 5, (doi:10.1038/ncomms4842)
Impact Factor: 11.47
• Lisandro H Otero, Alzoray Rojas-Altuve, Leticia I Llarrull, Malika Kumarasiri, Elena Lastochkin, Jennifer
Fishovitz, Matthew Dawley, Dusan Hesek, Mijoon Lee, Jarrod W. Johnson, Jed F. Fisher, Mayland Chang,
Shahriar Mobashery* and Juan A. Hermoso*
How allosteric control of Staphylococcus aureus penicillin-binding protein 2a enables methicillin-resistance and
physiological function. Proceedings of the National Academy of Sciences USA (PNAS) (2013); 110, 1680816813.
Impact Factor: 9.80
• Lee, M.; Artola-Recolons, C.; Carrasco-López, C.; Martínez-Caballero, S.; Hesek, D.; Spink, E.; Lastochkin, E.;
Zhang, W.; Hellman, L.; Boggess, B.; J.A. Hermoso* & S. Mobashery*
Cell-Wall Remodeling by the Zinc-Protease AmpDh3 from Pseudomonas aeruginosa
J. Am. Chem. Soc. (2013); 12605-12607.
Impact Factor: 12.11
• Siseth Martínez-Caballero, Mijoon Lee, Cecilia Artola-Recolons, César Carrasco-López, Dusan Hesek, Edward
Spink, Elena Lastochkin, Weilie Zhang, Lance M. Hellman, Bill Boggess, Shahriar Mobashery* and Juan A.
Hermoso*
Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. J.
Am. Chem. Soc. (2013); 135; 10318-10321.
Impact Factor: 12.11
• Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka,
Thomas Pribyl, Juan A. Hermoso* and Sven Hammerschmidt *
Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular
oxidative stress resistance and maintenance of virulence. EMBO Molecular Medicine. 2013; 5, 1852-1870.
(cover of the journal)
Impact Factor: 8.24
• Inmaculada Pérez-Dorado, Ana González, María Morales, Reyes Sanles, Waldemar Striker, Waldemar Vollmer,
Shahriar Mobashery, José L García, Martín Martínez-Ripoll, Pedro García & Juan A Hermoso*
Insights into pneumococcal fratricide from crystal structure of the modular Killing Factor LytC. Nature Structural &
Molecular Biology, (2010) Vol.17, N 5; 576-581.
Impact Factor: 11.50
• Molina, R., González, A., Stelter, M., Pérez-Dorado, I., Kahn, R., Morales, M., Campuzano, S., Campillo, N. E.,
Mobashery, S., García, J. L., García P., and Juan A. Hermoso*.
Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus
pneumoniae. EMBO reports. (2009) 10, 246-251.
Impact Factor: 8.662
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Juan A. Hermoso - CV
• Juan A. Hermoso*, José L García, Pedro García.
Taking aim on bacterial pathogens: from phage therapy to enzybiotics. Current Opinion in Microbiology (2007)
Vol 10/5, 461-472
Impact Factor: 7.45 (cover of the journal)
• Hermoso*, J.A., Lagartera, L., González, A., Stelter, M., García, P., Martínez-Ripoll, M., García, J.L., Menéndez
M. Insights into pneumococcal pathogenesis from crystal structure of the modular teichoic acid
phosphorylcholine esterase Pce. Nature Structural & Molecular Biology, (2005) Vol.12, N 6; 533-538.
Impact Factor: 11.50
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