Macias Group Report

2013
ANNUAL
REPORT
STRUCTURAL AND COMPUTATIONAL BIOLOGY
Structural characterisation of macromolecular assemblies
Group Leader
Maria J. Macias
Postdoctoral Fellows
Mads Beich-Frandsen*
James Gordon
Toni Todorovski*
PhD Students
Albert Escobedo
Tiago Lopes
Jordi Medina
Constanze Schelhorn
David Suñol
Research Assistants
Eric Aragón
Pau Martín
Lab Technician
Lidia Ruiz
*shared with another lab
HIGHLIGHTS
SMAD-binding proteins.
Inter- and intra-molecular interactions in E3 ubiquitin ligases.
Molecular and structural analysis of ribonucleoprotein complexes.
PUBLICATIONS
Martín-Gago P, Aragón E, Gomez-Caminals M, Fernández-Carneado J, Ramón R, MartinMalpartida P, Verdaguer X, López-Ruiz P, Colás B, Cortes MA, Ponsati B, Macias MJ and Riera A.
Insights into structure-activity relationships of somatostatin analogs containing mesitylalanine.
Molecules, 18 (12), 14564-84 (2013)
COLLABORATIONS
Structural and functional studies of somatostatin and derivatives
Antoni Riera, IRB Barcelona (Barcelona, Spain)
IRB BARCELONA
2013 ANNUAL REPORT
Characterization of the folding pathway of the FBP28 WW domain
Dr. Harold Scheraga, Baker Laboratory of Chemistry and Chemical Biology, Cornell University
(Ithaca NY, United States); Dr. Hartmut Oschkinat NMR-supported Structural Biology, LeibnizInstitut für Molekulare Pharmakologie (Berlin, Germany)
Protein-protein and protein-RNA complexes
Juan Valcárcel, Center for Genomic Regulation (Barcelona, Spain); Encarna Martínez, CSIC
(Madrid, Spain); Enrique Pedroso, Universidad de Barcelona (Barcelona, Spain)
Structural analysis of Smad proteins and complexes
Joan Massagué, Memorial-Sloan Kettering Cancer Center (New York, United States)
Structural analysis of proteins by X-ray crystallography
Fernando Gil, ALBA (Barcelona, Spain)
RESEARCH PROJECTS
Fosforilación de los Smads como regulación de su activación y degradación. Análisis estructural
mediante RMN de los complejos Smad, unidos a activadores y represores
Proyectos Investigación Fundamental, SAF2011-25119
Ministerio de Economía y Competitividad (MINECO), 2012-2014
Principal investigator: Maria J. Macias
Integrated approach to post-transcriptional regulation of gene expression and its role in human
disease
Consolider, CSD2009-00080
Ministerio de Economía y Competitividad (MINECO), 2009-2014
Principal investigator: Maria J. Macias