fisabio public health food safety

Transcripción

FISABIO
PUBLIC HEALTH
FOOD SAFETY
HEAD OF RESEARCH SECTION
DR CLARA COSCOLLÀ RAGA
COSCOLLA [email protected]
AVENIDA DE CATALUÑA, 21 / 46020 VALENCIA / SPAIN
FISABIO
FOOD SAFETY
The research carried out by the Food Safety Section of FISABIO-Public Health focuses
mainly on the development of analytical methods for the determination of pollutants and
residues in foods and environmental matrices,
and on the evaluation of the risks derived from
the presence of pollutants in food and in the
environment.
The research group members are affiliated to FISABIO-Public Health, the Laboratory
of Public Health of Valencia (Laboratorio de
Salud Pública de Valencia) and the Department of Food Safety of the General Directorate
of Public Health of the Conselleria de Sanidad
(Department of Health) of the Generalitat Valenciana (Government of Valencia).
OBJECTIVES
The main objectives of the research group of the Food Safety
Section are the following:
1. To develop new analytical, environmental monitoring and
risk assessment methods for persistent and emergent airborne
pesticides and pollutants.
2. To develop new analytical methods to detect and measure food and environmental pollutants in biological fluids, studying exposure and assessing risk.
3. To develop new analytical methods for the determination
of pollutants and residues of interest in food safety and environmental health.
4. Assessment of exposure and risks of high-priority and
emerging pollutants and residues capable of entering the food
chain.
FUNDACIÓN PAR A EL FOMENTO DE L A INVESTIGACIÓN SANITARIA Y BIOMÉDIC A DE L A COMUNIDAD VALENCIANA (FISABIO) / AVENIDA DE C ATALUÑA, 21 / 46020 VALENCIA / SPAIN
AREAS
OF RESEARCH
AREA 1. Airborne Pesticides
In this area, we study the presence of pesticides in air. We develop methods for capturing and analysing airborne agricultural pesticides, monitor their levels in ambient air and
their temporal and spatial trends, and assess
pesticide exposure and risk by inhalation.
Researchers of FISABIO-Public Health and
from the Fundación Centro de Estudios Ambientales del Mediterráneo (Mediterranean Center
for Environmental Studies [CEAM] Foundation)
have created the Atmospheric Pesticide Research Group of Valencia. This group carries
out studies on the transport, fate, behaviour
and atmospheric degradation of pesticides in
the environment through a combination of field
studies, laboratory experiments and computational simulations. The experimental studies on
the atmospheric degradation of pesticides are
conducted in a EUPHORE simulation chamber
that belongs to the CEAM.
RESEARCH PROJECTS
1. 2015-2018. Environmentally efficient
use of pesticides by localized irrigation systems (IRRILIFE). European Commission (LIFE14
ENV/ES/000119), LIFE Environment and Resource Efficiency. Funds: 784 325 €.
2. 2014-2015. Distribution and Impact of
Pesticides in the Atmosphere (DIPA). Funding
Institution: Conselleria de Educación (Department of Education) (GV/2014/005), funds
from the General Directorate of Scientific
Policy that awards grants to newly formed research groups for R&D projects. PI: Dr Clara
Coscollà. Funds: 6000 €.
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FISABIO
FOOD SAFETY
3. 2011-2012. Monitoring and impact of
airborne pesticides in the Autonomous Community of Valencia (CIPAV). Funding Institution:
Conselleria de Educación. Reference number:
GV/2011/007. PI: Dr Vicent Yusà Pelechà.
Funds: 10 800.00 €.
4. 2012. New methods for the collection
and analysis of pesticides from the gaseous
fraction of ambient air. Biomonitoring in humans. Funding Institution: Grants for the promotion of health care research in the Autonomous Community of Valencia. PI: Dr Vicent
Yusà. Number of participating researchers: 6.
Funds: 9000 €.
5. 2011. Impact of airborne pesticides:
levels in air and rain water, kinetics and atmospheric degradation. Funding Institution:
Ministerio de Ciencia e Innovación (Ministry of Science and Innovation). Participating
Institutions: CEAM, FISABIO. PI: Dr Amalia
Muñoz. Number of participating researchers:
6. Funds: 12 000 €.
6. 2010. Spatial and temporal distribution of commonly used pesticides in the atmosphere of the Autonomous Community of
Valencia. Funding Institution: Conselleria de
Sanidad. Participating Institutions: Laboratorio
de Salud Pública de Valencia-FISABIO, School
of Chemistry (University of Valencia), CEAM.
PI: Dr Vicent Yusà Pelechà. Number of participating researchers: 5. Funds: 3500 €.
7. 2009–2012. Development of new semipermeable membrane samplers: determination
of organic pollutants in water and air. Funding
Institution: Ministerio de Educación y Ciencia
(Ministry of Education and Science). Participating Institutions: School of Chemistry (University
of Valencia), Laboratorio de Salud Pública de
Valencia. PI: Dr Agustín Pastor. Number of participating researchers: 10. Funds: 120 000 €.
8. 2009. Airborne pesticide monitoring
in the Autonomous Community of Valencia.
Funding institution: Conselleria de Sanidad.
PI: Dr Vicent Yusà. Number of participating
researchers: 5. Funds: 4400 €.
9. 2007-2010. Study of pesticide behaviour in the atmosphere. Funding Institution:
Ministerio de Educación y Ciencia (CGL 200765223). Participating Institutions: Fundación
Centro de Estudios Ambientales del Mediterráneo (CEAM) and Laboratorio de Salud Pública
de Valencia (Government of Valencia) PI: Dr
Amalia Muñoz. Number of participating researchers: 9. Funds: 45 000 €.
10. 2007–2008. Atmospheric Fate and
Impact of Pesticides. Funding Institution: Interregional Cooperation Interreg IIIC South Zone.
Participating Institutions: Centre National de
la Recherche Scientifique (CNRS) of Orleans,
France; Fundación Centro de Estudios Ambientales del Mediterráneo (CEAM) and Laboratorio
de Salud Pública de Valencia (Generalitat Valenciana). PI: Wahid Mellouki. Number of participating researchers: 6. Funds: 76 287.48 €.
11. 2007-2008. Atmospheric degradation
of the pesticides used most frequently in the
Autonomous Community of Valencia. Funding
Institution: Conselleria de Empresa, Universidad y Ciencia (Department of Industry, University and Science, Generalitat Valenciana)
(GV/2007/257). Participating Institutions:
Fundación Centro de Estudios Ambientales
del Mediterráneo (CEAM) and Laboratorio de
Salud Pública de Valencia (Generalitat Valenciana) PI: Dr Amalia Muñoz. Number of participating researchers: 9. Funds: 12.200 €
RELEVANT PUBLICATIONS
1. López A., Yusà V., Millet M., Coscollà
C. Retrospective screening of pesticide metabolites in ambient air using liquid chromatography coupled to high-resolution mass spectrometry. Talanta (2016) 150:27-36.
2. Vera T., Borrás E., Chen J., Coscollá C,
Daële V., Mellouki A., Ródenas M., Sidebottom
H., Sun X., Yusá V., Zhang X., Muñoz A. Atmospheric degradation of lindane and 1,3-dichloroacetone in the gas phase. Studies at the
EUPHORE simulation chamber. Chemosphere
(2015) 138: 112-119.
3. Yusà V, Coscollà C, Millet M. New
screening approach for risk assessment of
pesticides in ambient air Atmospheric Environment (2014) 96; 322-330.
4. Coscollà C., Muñoz A., Borras E., Vera
T., Ródenas M., Yusà V. Particle size distributions of Currently Used pesticides in ambient
air of an agricultural Mediterranean area. Atmospheric Environment (2014) 95; 29-35.
5. Borrás E., Tortajada- Genaro L.A.,
Rodenas M., Vera T., Coscollà C., Yusa V.,
Muñoz A. Gas-phase degradation of the herbicide ethalfluralin Ander atmospheric conditions. Chemosphere (2014) 95:395-401.
6. Coscollà C., Yahyaoui A., Colin P.,
Robin C., Martinon L., Val S., Baeza-Squiban
A., Mellouki A., Yusà V. Particle size distributions of Currently Used pesticides in a rural atmosphere of France. Atmospheric Environment
(2013) 81; 32-38.
7. Coscollà C., Hart E., Pastor A., Yusà
V. LC-MS characterization of contemporary
pesticides in PM10 of Valencia Region, Spain.
Atmospheric Environment (2013) 77;394-403.
9. Coscollà C., Castillo M., Pastor A.,
Yusà V. Determination of 40 currently used
pesticides in airborne particulate matter (PM
10) by microwave-assisted extraction and gas
chromatography coupled to triple quadrupole
mass spectrometry. Analytica Chimica Acta
(2011) 693;72-81.
AREA 2. Biomonitoring
In this area, we develop new laboratory
methods to analyse food and environmental
pollutants in biological fluids and tissues, such
as human milk, urine or hair. We also study the
exposure to persistent and emergent pollutants
of the general population and more vulnerable
subpopulations, such as children and pregnant
women. Furthermore, we characterise associated environmental and dietary factors, and
perform risk assessments.
RESEARCH PROJECTS
1. 2012-2014. DENAMIC – Developmental
Neurotoxicity Assessment of Mixtures in Children. Funding institution: European Commission. Reference number: FP7-ENV.2011.1.2.2-1.
PI of the international project: P. Leonard.
Funds: 463 472.00 €.
2. 2011–2012. Monitoring and assessment of the impact of airborne pesticides in
the Autonomous Community of Valencia (CIPAV). Funding Institution: Conselleria de Educación. Reference number: GV/2011/007. PI:
Dr Vicent Yusà Pelechà. Funds: 10.800,00 €.
3. 2015–2016. Infant exposure to persistent and emerging pestidides through breast
milk. Characterization of associated environmental and dietary factors and risk assessment
(BETTERMILK). Funding Institution: Conselleria de Educación. PI: Dr Marta Roca. Funds:
12 000 €.
AREA 3. New analytical methods
This area involves the development of
new analytical methods for the determination
of pollutants and residues of interest in food
safety and environmental health. This area
aims at providing analytical support to different programmes and projects, and to carry out
the technological translations that allow the
application of these methods to governmental
surveillance efforts.
We develop analytical methods with a
high sensitivity, specificity and confirmatory power in the field of veterinary residues,
pesticides, environmental pollutants and others, usually based on liquid chromatography
(LC) and gas chromatography (GC) coupled
to tandem mass spectrometry (MS/MS) and
high-resolution accurate-mass spectrometry
(LC-HRMS).
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FISABIO
FOOD SAFETY
8. Hart E., Coscollà C., Pastor A., Yusà
V. GC-MS characterization of contemporary
pesticides in PM10 of Valencia Region, Spain.
Atmospheric Environment (2012) 62:118-29.
10. Coscollà C., Colin P., Yahyaoui A.,
Petrique O., Yusà V., Mellouki A., Pastor A.
Occurrence of currently used pesticides in
ambient air of Centre Region (France). Atmospheric Environment (2010) 44:3915-25.
1. Sanchis Y., Coscollà C., Roca M., Yusa
V. Target analysis of primary aromatic amines
combined with a comprehensive screening of
migrating substances in kitchen utensils by
liquid chromatography-high resolution mass
spectrometry. Talanta (2015) 138:290 -7.
2. C., Navarro-Olivares S., Martí P., Yusà
V. Application of the experimental design of
experiments (DoE) for the determination of
organotin compounds in water samples using
HS -SPME and GC-MS/MS. Talanta (2014)
119:544-52.
3. Moragues F., Igualada C., Leon N. Validation of the Determination of Chloramphenicol Residues in Animal Feed by Liquid Chromatography with an Ion Trap Detector Based on
European Decision 2002/657/EC. Food Anal
Meth. (2012) 5:416 -21.
4. León N., Roca M., Igualada C., Martin
CPB., Pastor A., Yusá V. Wide-range screening of banned veterinary drugs in urine by
ultra high liquid chromatography coupled to
high-resolution mass spectrometry. Journal of
Chromatography A (2012) 258:55- 65.
5. Castillo M., Carbonell E., González C.,
Miralles Marco A. Residue Analysis in Animal
Origin Food: Procedure Proposal and Evaluation for Lipophilic Pesticides. In: Soundararajan RP, editor. Pesticides – Recent Trends in
Pesticide Residue Assay. INTECH; 2012.
6. Beltrán E., Ibáñez M., Sancho JV.,
Cortés MÁ., Yusà V., Hernández F. UHPLC-MS/
MS highly sensitive determination of aflatoxins, the aflatoxin metabolite M1 and ochratoxin A in baby food and milk. Food Chem.
(2011) 126(2):737-44.
7. Castillo M., González C., Miralles A.
An evaluation method for determination of
non-polar pesticide residues in animal fat samples by using dispersive solid-phase extraction
clean-up and GC-MS. Anal Bioanal Chem.
(2011) 400(5):1315-28.
AREA 4. Exposure assessment
Assessment of exposure to high-priority
and emerging pollutants and residues that
could enter the food chain and of associated risks. Exposure assessment is performed by
means of various methods, including whole-diet studies, data obtained from governmental
surveillance programmes, and biomonitoring.
RESEARCH PROJECTS
1. 2008–2011. Whole-diet study in the
Institution: Conselleria de Sanitat. Participating Institutions: AINIA, Laboratorio de Salud
Pública de Valencia. PI: Silvia Marín, Vicent
Yusà. Number of participating researchers:
10. Funds: 760 000 €.
2. 2015–2016. Assessment of pesticide
exposure and related risks through consumption of plant products in the population of the
institution: FISABIO. PI: Olga Pardo. Funds:
7800 €.
1. Pardo O., Beser MI., Yusà V., Beltrán J.
Probabilistic risk assessment of the exposure
to polybrominated diphenyl ethers via fish and
seafood consumption in the Region of Valencia (Spain). Chemosphere (2014) 104:7-14.
2. Marin S., Villalba P., Diaz-Ferrero J.,
Font G., Yusà V. Congener profile, occurrence
and estimated dietary intake of dioxins and
dioxin-like PCBs in foods marketed in the Region of Valencia (Spain). Chemosphere (2011)
82(9):1253- 61.
3. Pardo-Marin O., Yusa-Pelecha V., Villalba- Martin P., Pérez-Dasi JA. Monitoring
programme on nitrates in vegetables and vegetable- based baby foods marketed in the Region of Valencia, Spain: levels and estimated
daily intake. Food Addit Contam Part A (2010)
27(4):478-86.
“New analytical
strategies for Food and
Environmental Safety.”
05
FISABIO
FOOD SAFETY
8. Juan C., Igualada C., Moragues F., Leon
N., Manes J. Development and validation of a
liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists
in animal feed and drinking water. Journal of
Chromatography A (2010)1217(39):6061-8.
RESEARCH
GROUP
RESEARCH GROUP COORDINATOR
DR CL ARA COSCOLL À RAGA
COSCOLL A _CL [email protected]
GROUP MEMBERS
DR VICENT YUSÀ PELECHÀ
DÑA. Mª ISABEL BESER SANTOS
YUSA [email protected]
BESER_ [email protected]
DR PEDRO MARTÍ REQUENA
DR FRANCISCO MORAGUES RIBES
[email protected]
[email protected]
DÑA. CARMEN IGUAL ADA CAÑAS
DÑA. NURIA LEÓN RUIZ
IGUAL ADA [email protected]
[email protected]
DR SILVIA MARÍN VILLUENDAS
D. JOSÉ ANTONIO AMORÓS CHILLIDA
[email protected]
AMOROS_ [email protected]
DÑA. ROSA Mª PÉREZ TORRES
DR ROSARIO BAGUENA MONTESINOS
[email protected]
BAGUENA [email protected]
D. ANTONIO LÓPEZ TOBARUEL A
DR OLGA PARDO MARÍN
D. PABLO DUALDE MARÍN
[email protected]
DÑA. YOVANA SANCHIS BOIX
DR LOURDES ZUBELDIA L AUZURICA
[email protected]
ZUBELDIA [email protected]
FOR MORE INFORMATION ON FISABIO’S ACTIVITIES AND SERVICES:
06
FISABIO
FOOD SAFETY
W. FISABIO.SAN.GVA.ES / T. +34 961925700 / M. [email protected]
THE ELABORATION OF THIS DOCUMENT HAS BEEN FUNDED BY THE PROJECT AFI-01/14, IN THE CONTEXT OF THE GRANTS FOR PARTICIPATION IN EUROPEAN COMMISSION RESEARCH PROGRAMMES ON HEALTH GIVEN BY THE CONSELLERIA DE SANITAT UNIVERSAL I
SALUT PÚBLICA OF THE GOVERNMENT OF VALENCIA FOR THE 2014-2015 FISCAL PERIOD.

fisabio public health food safety

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