- OTL Udec

PHARMACEUTICAL
INJECTABLE
PHARMACEUTICAL
FORMULATION FOR
TREATING ALCOHOL
DEPENDENCE THAT
REQUIRES MONTHLY
ADMINISTRATION
OTL UdeC
Oficina de Transferencia y Licenciamiento
Alcoholism is a chronic, progressive disease that manifests itself with symptoms that affect one physically, mentally, emotionally, spiritually and socially.
One of the main problems in treating alcohol dependants is the low adherence
.
to treatment, for it requires their will to take a daily pill or not to rip off a pellet.
The University of Concepción developed a new inclusion complex formed by
disulfiramand cyclodextrins, formulated as an inyectable, which allows maintaining stable therapeutic plasma levels of this drug from the beginning of the
administration, with a proven clinical efficacy for 30 days, with minimal
irritation in the administration area.
A comparative study (tested against oral disulfiram) performed on 48 patients
during 6 months of treatment evidenced that this new injectable formulation:
facilitates treatment, requires less supervision (monthly vs. daily), increases
bonding in patient/physician relation, has an adherence to the treatment 41,4%
higher than oral disulfiram, increases abstinence (10.6% higher than oral
disulfiram) and requires a minor drug intake per month (1.5 gr. Injectable vs.
15 gr. injectable) which is a key factor for preventing hepatotoxicity.
From a clinical point of view this new complex is a pharmacological tool that
further supports the biopsychosocial treatment of alcohol dependence, increasing the level of adherence to treatment and reducing the relapse after treatment.
It may also be used in the treatment of cocaine dependence.
RESEARCHERS
Jacqueline Sepúlveda Carreño
Pharmacology Department
Faculty of Biological Sciences
Carlos von Plessing Rossel
Pharmacy Department
Faculty of Pharmacy
INTELLECTUAL PROPERTY
International applications
PCT/IB2008/003695 and
PCT/IB2008/003696
Sandra Araya Tapia
Directora Ejecutiva
Oficina de Transferencia y Licenciamiento
[email protected]
(56 - 41) 2207489
Edificio Empreudec
Barrio Universitario s/n
Concepción, Chile
(56 - 41) 2204509
www.otludec.cl