How Nasal Allergy Can Help - Children`s FLONASE® Allergy Relief

How Nasal Allergy Can Help - Children`s FLONASE® Allergy Relief

HOW NASAL ALLERGY
SPRAYS CAN HELP
What happens when you have allergies?
HAYFEVER / 0.05% NASAL SPRAY
Triggered
Cell
HAYFEVER / 0.05% NASAL SPRAY
Allergen
Inflammatory
Substances
Allergies start when you breathe in allergens like
pollen or pet dander. Your body mistakes the
allergen for an invader, and your immune
system responds.1-4
How do nasal allergy
sprays work?
Nasal allergy sprays work right
in your nose to help block your
allergic reaction and relieve
your symptoms.1,6,7
Your body’s natural response is to release
multiple inflammatory substances that cause
your allergy symptoms.1,5
Intranasal corticosteroid (INS) allergy
sprays act on multiple inflammatory
substances,* while single-ingredient
antihistamines act on histamine.1-3,8,9
Single-ingredient
antihistamines
INS
Histamine
Cytokines
Leukotrienes
Chemokines
Prostaglandins
Tryptases
It is best to use an INS spray
regularly. It may take several
days for treatment with a
nasal allergy spray to reach
maximum effect.6
Nasal allergy sprays relieve
sneezing, itchy nose, runny
nose, and nasal congestion.
FLONASE® Allergy Relief is the
only OTC INS† spray indicated to
relieve itchy, watery eyes.6,7,10,11
* Mechanism vs. most OTC allergy pills.
FLONASE® acts on multiple inflammatory
substances (histamine, prostaglandins,
cytokines, tryptases, chemokines and
leukotrienes). The exact number
and precise mechanism
are unknown.
†
Glucocorticoid.
References: 1. Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63(10):1292-1300.
2. Hallgren J, Pejler G. Biology of mast cell tryptase: an inflammatory mediator. FEBS J. 2006;273(9):1871-1895. 3. Broide DH. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc.
2007;28(4):398-403. 4. Overview of the immune system. National Institute of Allergy and Infectious Diseases website. http://www.niaid.nih.gov/topics/immuneSystem/Pages/overview.aspx.
Accessed June 2, 2014. 5. IGE’s role in allergic asthma. Asthma and Allergy Foundation of America website. https://www.aafa.org/print.cfm?id=8&sub=16&cont=54. Accessed August 21, 2014.
6. FLONASE drug facts label. 7. WebMD. Can nasal steroids ease allergy symptoms? http://www.webmd.com/allergies/nasal-steroids. Updated March 14, 2013. Accessed August 29, 2014.
8. Small P, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol. 2011;7(suppl 1):S3. 9. Church DS, Church MK. Pharmacology of antihistamines. World Allergy Organ J. 2011;4(3 suppl):S22-S27.
10. Nasacort Drug Facts Label. 11. Nasacort [patient information leaflet]. Cheshire, UK: Aventis Pharma; 2013.
FLONASE, the FLONASE logo, the bottle and cap designs, and other design elements are trademarks of the GSK group of companies.
©2015 GSK group of companies. All rights reserved. Produced in USA. July 2015
COMPRENDA COMO LOS
AEROSOLES NASALES PARA LAS
ALERGIAS PUEDEN AYUDAR
¿Qué sucede cuando tiene alergias?
HAYFEVER / 0.05% NASAL SPRAY
Célula
desencadenada
HAYFEVER / 0.05% NASAL SPRAY
Alérgeno
Sustancias
inflamatorias
Las alergias comienzan cuando se respiran
alérgenos, como el polen o la caspa de las mascotas.
El cuerpo confunde el alérgeno con un invasor y el
sistema inmunológico responde.1-4
¿Cómo actúan los
aerosoles nasales
para las alergias?
Los aerosoles nasales para las
alergias funcionan justo en la
nariz para ayudar a bloquear las
reacciones alérgicas y aliviar los
síntomas.1,6,11
La respuesta natural del cuerpo es liberar
múltiples sustancias inflamatorias que causan
síntomas alérgicos.1,5
Los aerosoles para las alergias con
corticosteroides intranasales (Intranasal
Corticosteroid, INS)† actúan sobre
múltiples sustancias inflamatorias,*
mientras que los antihistamínicos de
un solo ingrediente actúan sobre la
histamina.1-3,7,8
Antihistamínicos
de un solo
ingrediente
Corticosteroide
intranasal
Histamina
Citocinas
Leucotrienos
Quimiocinas
Prostaglandinas
Triptasas
Es mejor usar un aerosol INS
con regularidad. El tratamiento
con un aerosol nasal para las
alergias puede tardar algunos
días para lograr el máximo
efecto.6
Los aerosoles nasales para las
alergias alivian los estornudos,
la picazón en la nariz, la gotera
nasal y la congestión nasal.
FLONASE® Allergy Relief es el
único aerosol INS disponible
sin receta indicado para aliviar
la picazón en los ojos y el
lagrimeo.6,7,10,11
* Mecanismo en comparación con la mayoría de las píldoras para la alergia
sin receta médica. FLONASE actúa sobre múltiples sustancias
inflamatorias (histamina, prostaglandinas,
citocinas, triptasas, quimiocinas y
leucotrienos). Se desconocen la
cantidad exacta y el
mecanismo precisos.
†
Glucocorticoide.
References: 1. Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63(10):1292-1300.
2. Hallgren J, Pejler G. Biology of mast cell tryptase: an inflammatory mediator. FEBS J. 2006;273(9):1871-1895. 3. Broide DH. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc.
2007;28(4):398-403. 4. Overview of the immune system. National Institute of Allergy and Infectious Diseases website. http://www.niaid.nih.gov/topics/immuneSystem/Pages/overview.aspx.
Accessed June 2, 2014. 5. IGE’s role in allergic asthma. Asthma and Allergy Foundation of America website. https://www.aafa.org/print.cfm?id=8&sub=16&cont=54. Accessed August 21, 2014.
6. FLONASE drug facts label. 7. WebMD. Can nasal steroids ease allergy symptoms? http://www.webmd.com/allergies/nasal-steroids. Updated March 14, 2013. Accessed August 29, 2014.
8. Small P, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol. 2011;7(suppl 1):S3. 9. Church DS, Church MK. Pharmacology of antihistamines. World Allergy Organ J. 2011;4(3 suppl):S22-S27.
10. Nasacort Drug Facts Label. 11. Nasacort [patient information leaflet]. Cheshire, UK: Aventis Pharma; 2013.
FLONASE, the FLONASE logo, the bottle and cap designs, and other design elements are trademarks of the GSK group of companies.
©2015 GSK group of companies. All rights reserved. Produced in USA. July 2015